AGER / RAGE Protein

Produkt-Information von AGER / RAGE Protein

QC Testing von AGER / RAGE Protein

Purity	> 78 % as determined by SDS-PAGE	SDS-PAGE: AGER / RAGE protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ala 23
Molecular Mass	The recombinant human AGER consists of  322 amino acids and predicts a molecular mass of 34.2 KDa. It migrates as an approximately 48 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von AGER / RAGE Protein

Verwandte Produkte & Themen von AGER / RAGE Protein

Beschreibung von AGER / RAGE Protein

Advanced glycosylation end product-specific receptor, also known as receptor for advanced glycosylation end products, AGER and RAGE, is a single-pass type I membrane protein. AGER / RAGE contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. AGER / RAGE mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. AGER / RAGE acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE / RAGE signaling plays an important role in regulating the production / expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction between AGER / RAGE and S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction between AGER / RAGE and S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. AGER / RAGE contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons.

References

1. Sugaya K. et al., 1994, Genomics. 23: 408-19.
2. Neeper M. et al., 1992, J Biol Chem. 267: 14998-5004.
3. Xie T. et al., 2003, Genome Res. 13: 2621-36.
4. Moroz OV. et al., 2009, BMC Biochem. 10: 11.
5. Fang F. et al., 2010, FASEB J. 24: 1043-55.

Sino Biological Inc. liefert AGER / RAGE Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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