MZB1 / PERP1 Protein (His Tag)

09.06.2013

Sino Biological Inc. liefert MZB1 / PERP1 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über MZB1 / PERP1 Protein (His Tag) lesen Sie bitte:http://www.sinobiological.com/PERP1-MZB1-Protein-Antibody-a-6259.html

Produkt-Information von MZB1 / PERP1 Protein

Synonym	MGC29506, MZB1,MEDA7, PACAP
Protein Construction	A DNA sequence encoding the human MGC29506 (Q8WU39-1) (Met 1- Thr 185) was expressed with a polyhistidine tag at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von MZB1 / PERP1 Protein

Purity	(61+35.7) % as determined by SDS-PAGE	SDS-PAGE: MZB1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Asp 23
Molecular Mass	The recombinant human MGC29506 consists of 174 amino acids and predicts a molecular mass of 19.4 KDa. It migrates as an approximately 22 and 20 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von MZB1 / PERP1 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von MZB1 / PERP1 Protein

PERP1, also known as MZB1, is an endoplasmic reticulum-localized and B cell-specific protein that is most abundantly expressed in marginal zone (MZ) B and B1 cells. PERP1 helps to diversify peripheral B cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation. PERP1 also associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. It may exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Methylation-mediated silencing of MZB1 expression leads to loss of its tumor-suppressive activity, which may be a factor in the hepatocarcinogenesis, and is a useful prognosticator in HCC.

References

Vinayagam A. et al., 2011, Sci Signal. 4 (189): rs8.
Matsumura S. et al., 2012, Clin Cancer Res. 18 (13): 3541-51.
Flach H. et al., 2010, Immunity. 33 (5): 723-35.