Mouse SMAD3 Protein (GST Tag) (Cytokine)

Sino Biological Inc. liefert Mouse SMAD3 Protein (GST Tag) (Cytokine) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse SMAD3 Protein (GST Tag) (Cytokine) lesen Sie bitte: http://www.sinobiological.com/SMAD3-Protein-Antibody-a-5772.html

Produkt-Information von SMAD3 Protein

QC Testing von SMAD3 Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: SMAD3 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant mouse SMAD3/GST chimera consists of 662 amino acids and has a calculated molecular mass of 75.9 kDa. The recombinant protein migrates as an approximately 75 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 20mM Tris, 500mM NaCl, 2mM GSH, 10% glycerol, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von SMAD3 Protein

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Beschreibung von SMAD3 Protein

SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 is involved in cell signalling. It modulates signals of activin and TGFβ's. Binding of SMAD3 with SMAD4 enables its transmigration into the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD3 is a receptor-regulated SMAD (R-SMAD). In mice, mutation of SMAD3 has been linked to colorectal adenocarcinoma, increased systemic inflammation, and accelerated wound healing. Increased SMAD3 activity has been implicated in the pathogenesis of scleroderma. Smad3 is also a multifaceted regulator in adipose physiology and the pathogenesis of obesity and type 2 diabetes.

References

1. Tan. et al., 2011, Diabetes. 60 (2): 464-76.
2. Yang X. et al., 1999, Nat Cell Biol. 1 (5): 260-6.
3. Zhu Y. et al., 1998, Cell. 94 (6): 703-14.
4. Feng X. et al., 1996, Nature. 383 (6596): 168-72.

• What is Cytokine
• Cytokine Production
• Cytokine Signaling
• Cytokine Storm
• Cytokine Therapy
• Inflammatory Cytokines