Mouse Biglycan / PG-S1 / BGN Protein

15.04.2013

Sino Biological Inc. liefert Mouse Biglycan / PG-S1 / BGN Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse Biglycan / PG-S1 / BGN Protein lesen Sie bitte: http://www.sinobiological.com/Biglycan-Protein-Antibody-a-5903.html

Produkt-Information von Biglycan / PG-S1 / BGN Protein

Synonym	BGN
Protein Construction	A DNA sequence encoding the mouse BGN (Met1-Lys369) was expressed with the Fc region of human IgG1 at the C-terminus.
Source	Mouse
Expression Host	Human Cells

QC Testing von Biglycan / PG-S1 / BGN Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: Biglycan protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 20
Molecular Mass	The recombinant mouse BGN /Fc is a disulfide-linked homodimer. The reduced monomer comprises 591 amino acids and has a predicted molecular mass of 66.5 KDa. The apparent molecular mass of the protein is approximately 67 KDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von Biglycan / PG-S1 / BGN Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von Biglycan / PG-S1 / BGN Protein

Biglycan, also known as PG-S1 and BGN, is a a small leucine-rich repeat proteoglycan (SLRP). It can be detected in a variety of extracellular matrix tissues, including bone, cartilage and tendon. Biglycan consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Non-glycanated forms of biglycan (no GAG chains) increase with age in human articular cartilage. Biglycan interacts with collagen, both via the core protein and GAG chains. Biglycan plays a role in the mineralisation of bone. Biglycan core protein binds to the growth factors BMP-4 and influences its bioactivity.

References

Harrach B. et al., 1995, The Journal of Biological Chemistry. 270 (6): 2776-83.
Young MF. et al., 1989, The Journal of Biological Chemistry. 264 (8): 4571-6.
Liu J. et al., 1993, The Biochemical Journal. 295 (2): 421-6.
White RJ. et al., 1989, The Biochemical Journal. 262 (3): 823-7.

Biglycan related areas, pathways, and other information