Mouse SDC4 / Syndecan-4 Protein

23.05.2013

Sino Biological Inc. liefert Mouse SDC4 / Syndecan-4 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse SDC4 / Syndecan-4 Protein lesen Sie bitte: http://www.sinobiological.com/Syndecan-4-SDC4-Protein-a-2552.html

Produkt-Information von SDC4 / Syndecan-4 Protein

Synonym	SDC4
Protein Construction	A DNA sequence encoding the mouse SDC4 (O35988)(Met1-Val146) was expressed with the Fc region of human IgG1 at the C-terminus.
Source	Mouse
Expression Host	Human Cells

QC Testing von SDC4 / Syndecan-4 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: SDC4 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 24
Molecular Mass	The recombinant mouse SDC4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 364 amino acids and has a predicted molecular mass of 40.5 kDa. The apparent molecular mass of the protein is approximately 33 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von SDC4 / Syndecan-4 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von SDC4 / Syndecan-4 Protein

Syndecan-4 (SDC4, Syn4), is a ubiquitous transmembrane proteoglycan that localizes to the focal adhesions of adherent cells and binds to a range of extracellular ligands, including growth factors and extracellular-matrix proteins. Through its extracellular domain, syndecan-4 cooperates with adhesion molecules and binds matrix components relevant for cell migration. As a heparan sulfate proteoglycan, SDC4 works as a coreceptor for various growth factors. Syn4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cells (VSMCs) proliferation and vascular progenitor cells (VPCs) mobilization. Therefore, Syn4 may be a novel therapeutic target for preventing arterial restenosis after angioplasty.

References

Bass MD. et al., 2002, Biochem J. 368 (1): 1-15.
Ikesue M. et al., 2011, Arterioscler Thromb Vasc Biol. 31 (5): 1066-74.
Rodríguez-Manzaneque JC. et al., 2009, Int J Biochem Cell Biol. 41 (4): 800-10.