Mouse FLRT2 Protein (His Tag)

23.05.2013

Sino Biological Inc. liefert Mouse FLRT2 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse FLRT2 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/FLRT2-Protein-a-1597.html

Produkt-Information von FLRT2 Protein

Synonym	FLRT2
Protein Construction	A DNA sequence encoding the mouse FLRT2 (Q8BLU0) (Met1-Ser539) was expressed with a C-terminal polyhistidine tag.
Source	Mouse
Expression Host	Human Cells

QC Testing von FLRT2 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: FLRT2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Cys 36
Molecular Mass	The recombinant mouse FLRT2 comprises 515 amino acids and has a predicted molecular mass of 57.6 kDa. The apparent molecular mass of the protein is approximately 68-78 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von FLRT2 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von FLRT2 Protein

Fibronectin Leucine Rich Transmembrane protein 2 ( FLRT2 ) is a Single-pass type I membrane protein. FLRT1, FLRT2 and FLRT3 are belong to Fibronectin Leucine-Rich Transmembrane (FLRT) family, and have been previously reported to be widely expressed in the developing embryo. The FLRT2 proteins contain 10 leucine-rich repeats (LRR), a type I II fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. Each member of the FLRT family has a distinct, highly regulated expression pattern, as was seen for the NLRR family. FLRT2 is expressed in a subset of the sclerotome, adjacent to the region that forms the syndetome, suggesting that interaction with FGF signalling may be a general property of FLRT proteins. All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. FLRT proteins can physically interact and that FLRT-transfected cultured cells sort out from non-transfected cells, suggesting a change in adhesive properties. FLRT proteins have a dual role, promoting FGF signalling and modulating homotypic cell adhesion.

References

Gong SG. et al., 2009, Gene Expr Patterns. 9(7): 497-502.
Maretto S. et al., 2008, Dev Biol. 318(1): 184-93.
Haines BP. et al., 2006, Dev Biol. 297(1): 14-25.
Karaulanov EE. et al., 2006, EMBO Rep. 7(3): 283-90.