Mouse PGRL / IGSF8 Protein (His Tag)

Sino Biological Inc. liefert Mouse PGRL / IGSF8 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse PGRL / IGSF8 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/PGRL-IGSF8-Protein-g-9942.html

Produkt-Information von PGRL / IGSF8 Protein

QC Testing von PGRL / IGSF8 Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: PGRL protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Arg 26
Molecular Mass	The recombinant mouse IGSF8 comprises 563 amino acids and has a predicted molecular mass of 60.2 kDa. The apparent molecular mass of the protein is approximately 66 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von PGRL / IGSF8 Protein

Verwandte Produkte & Themen von PGRL / IGSF8 Protein

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>IGSF8/CD316

Immunology>>Cluster of Differentiation>>Other>>IGSF8/CD316

Beschreibung von PGRL / IGSF8 Protein

Immunoglobulin superfamily member 8, also known as IGSF8, PGRL, and CD316, is a single-pass membrane protein with a short cytoplasmic domain interacting with membrane PIPs and mediating plasma membrane localization. It is expressed in brain, kidney, testic, liver and placenta with moderate expression in all other tissues. This protein has been detected on a majority of B-cells, T-cells, and nature killer cells but not on monocytes, polynuclear cells and platelets. IGSF8 may play a role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. It also regulate proliferation and differentiation of keratinocytes. IGSF8 may be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. It may also play a role on integrin-dependent morphology and motility functions and participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.

References

1. Glazar AI. et al., 2009, Reprod Fertil Dev. 21 (2): 293-303.
2. Murdoch JN. et al., 2003, Mol Cell Neurosci. 22 (1): 62-74.
3. Zhang XA. et al., 2003, Cancer Res. 63 (10): 2665-74.