Rat IL1RN / IL1RA Protein

Sino Biological Inc. liefert Rat IL1RN / IL1RA Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat IL1RN / IL1RA Protein lesen Sie bitte: http://www.sinobiological.com/IL1RN-IL1RA-Protein-g-9946.html

Produkt-Information von IL1RN / IL1RA Protein

QC Testing von IL1RN / IL1RA Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: IL1RN protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant rat IL1RN comprises 412 amino acids and predicts a molecular mass of 45.8 kDa. The apparent molecular mass of  the recombinant protein is approximately 47 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL1RN / IL1RA Protein

Verwandte Produkte & Themen von IL1RN / IL1RA Protein

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-1RA/IL-1F3

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family >>IL-1RA/IL-1F3

Beschreibung von IL1RN / IL1RA Protein

IL1 is an important prototypic pro-inflammatory cytokine that affects multiple cell types, often in concert with another cytokine, tumor necrosis factor (TNF). There are two forms of IL1, IL1α. and IL1β, whose function are mediated by the two specific receptors on the cell surfaces. The IL1 receptor antagonist (IL1RA), formerly called the IL1 inhibitor, is a member of the IL1 cytokine family which binds to the same receptor (IL1R) as IL1, and thus prevents IL1 from signal transduction without interaction with the IL1 molecules. In terms of protein similarities,IL1RA is more closely related to IL1β than it is to IL1α. IL1RA modulates a variety of IL1-related immune and inflammatory responses, and accordingly, the balance between IL1 and IL1Ra in local tissues plays an important role in the susceptibility to and severity of many diseases. IL1RA is suggested to have possible therapeutic applications in treatment of sepsis, rheumatoid arthritis, and chronic myelogenous leukemia. Four alternatively spliced transcript variants encoding distinct isoforms have been identified, and the isoform 1 of IL1RA is secreted from monocytes, macrophages, neutrophils, and other cells.

References

1. Haskill S. et al., 1991, Proc Natl Acad Sci. 88: 3681-5.
2. Sehouli J. et al., 2002, Anticancer Res. 22: 3421-4.
3. Arend WP. e t al., 1998, Annu Rev Immunol. 16: 27-55.
4. Dinarello CA. et al., 1997, Cytokine Growth Factor Rev. 8: 253-65.