Mouse Interleukin-2 / IL-2 Protein (Native)

Produkt-Information von Interleukin-2 / IL-2 Protein

QC Testing von Interleukin-2 / IL-2 Protein

Purity	> 92 % as determined by SDS-PAGE	SDS-PAGE: Interleukin-2 / IL-2 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant mouse IL2 consists of 150 amino acids and has a calculated molecular mass of 17.4KDa. It migrates as an approximately 19 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, 2mMDTT, PH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von Interleukin-2 / IL-2 Protein

Verwandte Produkte & Themen von Interleukin-2 / IL-2 Protein

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>IL-2/IL2/TCGF

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL-2/IL2/TCGF

Cancer>>Growth Factor & Receptor>>Other>> Interleukin 2 / IL2

Immunology>>Adaptive Immunity>>T Cell>>T Cell Migration/Adhesion>> Interleukin 2 / IL2

Immunology>>Adaptive Immunity>>B Cell>> Interleukin 2 / IL2

Beschreibung von Interleukin-2 / IL-2 Protein

Interleukin-2, also known as T-cell growth factor, TCGF, Aldesleukin and IL2, is a secreted protein which belongs to the IL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleukin-2 / IL-2 molecule was first purified to homogeneity by immunoaffinity chromatography by Kendall Smith and his team at Dartmouth Medical School. Interleukin-2 / IL-2 was also the first cytokine shown to mediate its effects via a specific IL-2 receptor, and it was also the first interleukin to be cloned and expressed from a complementary DNA (cDNA) library. Interleukin-2 / IL-2 was designated number 2 because Smith's data at the time indicated that IL-1, produced by macrophages, facilitates IL-2 production by T lymphocytes (T cells). Interleukin-2 / IL-2 is produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Interleukin-2 / IL-2 is normally produced by the body during an immune response. When environmental substances (molecules or microbes) gain access to the body, these substances (termed antigens) are recognized as foreign by antigen receptors that are expressed on the surface of lymphocytes. Antigen binding to the T cell receptor (TCR) stimulates the secretion of Interleukin-2 / IL-2, and the expression of IL-2 receptors IL-2R. The IL-2 / IL-2R interaction then stimulates the growth, differentiation and survival of antigen-selected cytotoxic T cells via the activation of the expression of specific genes. Interleukin-2 / IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. The World Reference Standard for Interleukin-2 / IL-2 is produced by the National Institute of Biological Standards and Control in the UK. A recombinant form of Interleukin-2 / IL-2 for clinical use is manufactured by Chiron Corporation with the brand name Proleukin. It has been approved by the Food and Drug Administration (FDA) for the treatment of cancers (malignant melanoma, renal cell cancer), and is in clinical trials for the treatment of chronic viral infections, and as a booster (adjuvant) for vaccines. The use of Interleukin-2 / IL-2 in HIV therapy has been found to be ineffective.

References

1. Smith KA. et al.,1980, J Exp Med.151 (6): 1551-6.
2. Smith KA. et al.,1980, Nature. 287 (5785): 853-5.
3. Taniguchi T. et al.,1983, Nature. 302 (5906): 305.
4. Cantrell DA. et al.,1984, Science. 224 (4655): 1312-6.
5. Smith KA. et al.,1988, Science. 240 (4856): 1169-76.
6. Wang X. et al., 2005, Science. 310: 1159-63.
7. Stauber DJ. et al., 2006, Proc Natl Acad Sci.103: 2788-93.

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