Canine IL33 / Interleukin-33 / NF-HEV Protein (Native)

03.05.2012

Produkt-Information von IL33 / Interleukin-33 / NF-HEV Protein

Synonym	DVS27
Protein Construction	A DNA sequence encoding the mature form of canine IL33 (O97863 ) (Ser 110-Ser 263) was expressed, with an initial Met at the N-terminus.
Source	Canine
Expression Host	E.coli

QC Testing von IL33 / Interleukin-33 / NF-HEV Protein

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: IL33 / Interleukin-33 / NF-HEV protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant canine IL33 consists of 155 amino acids and has a calculated molecular mass of 17.8 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 19KDa band.
Formulation	Lyophilized from 0.2μm filtered solution of 5mMEDTA PBS, pH7.5 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL33 / Interleukin-33 / NF-HEV Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von IL33 / Interleukin-33 / NF-HEV Protein

Related Areas:

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>IL-33

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-1 superfamily and IL-1R/TLR family>>IL-33

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-33	Human	IL-33/NF-HEV Protein, Recombinant	10368-HNAE
IL-33	Canine	IL33 / Interleukin-33 / NF-HEV Protein, Recombinant, with Native	70005-DNAE

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IL-33	WB	Mouse Monoclonal Antibody	10368-MM01
Human IL-33	ELISA	Mouse Monoclonal Antibody	10368-MM02
Human IL-33	IHC-P	IL-33 Antibody	10368-MM13
Human IL-33	WB, ELISA	Rabbit Polyclonal Antibody	10368-RP01
Human IL-33	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10368-RP02

Beschreibung von IL33 / Interleukin-33 / NF-HEV Protein

Interleukin-33 (IL-33), also known as DVS 27 and NF-HEV, is a proinflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 is expressed highly and rather selectively by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyers's patches, and lymph nodes. It contains a bipartite nuclear localization signal at the C-terminus, and is targeted to the nucleus when ectopically expressed in human umbilical vein endothelial cells (HUVECs) and HeLa cells. IL-33 mediates its biological effects via Toll-interleukin 1 receptor (TIR) domain-containing receptor ST2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines. IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.

References

Schmitz J. et al., 2005, Immunity. 23: 479-90.
Dinarello CA. 2005, Immunity. 23: 461-2.
Carriere V. et al., 2007, Proc Natl Acad Sci. 104 (1): 282-7.
Cayrol C.?et al., 2009, Proc Natl Acad Sci. 106 (22): 9021-6.

Sino Biological Inc. liefert Canine IL33 / Interleukin-33 / NF-HEV Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Canine IL33 / Interleukin-33 / NF-HEV Protein (Native) lesen Sie bitte: http://www.sinobiological.com/IL33-Interleukin-33-NF-HEV-Protein-g-8838.html