Mouse IL12B / IL-12B Protein (His Tag)

Sino Biological Inc. liefert Mouse IL12B / IL-12B Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von IL12B / IL-12B Protein

QC Testing von IL12B / IL-12B Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: IL12B protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met 23
Molecular Mass	The recombinant mouse IL12B comprises 324 amino acids and has a predicted molecular mass of 37.2 kDa. The apparent molecular mass of the protein is approximately 47-51 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL12B / IL-12B Protein

Verwandte Produkte & Themen von IL12B / IL-12B Protein

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-12B/IL-12p40

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>IL-12B/IL-12p40

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-12 Family & Receptor>>IL-12B/IL-12p40

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Macrophage Marker>>IL-12B/IL-12p40

Beschreibung von IL12B / IL-12B Protein

Interleukin 12 (IL-12), also known as NKSF or CLMF, is a disulfide-linked heterodimeric cytokine composed of a 35kDa subunit P35 and a 40kDa subunit P40, also designated as IL-12A and IL-12B. IL-12 is predominantly produced by macrophages and B lymphocytes and plays an important role in the activities of natural killer cells and T lymphocytes. It is involved in the differentiation and development of Th1 cells, enhancement of natural killer cells’ cytolytic function and mitogenic effects, as well as induction of IFN-gamma during which it can synergize with other IFN-gamma inducers. A large excess of monomeric IL-12B is also secreted by the cells producing IL-12, and exhibits no demonstrable biological activity. Overexpression of IL-12B has been shown to be associated with the pathogenesis of multiple sclerosis.

References

1. Ling, P. et al., 1995, J. Immunol. 154: 116-27.
2. Thierfelder, WE. et al., 1996, Nature. 382: 171-4.
3. Kato, K. et al., 1996, Proc. Natl. Acad. Sci. 93: 9085-89.
4. Kim, JH. et al., 1997, Clin. Exp. Immunol. 108: 243-50.