Canine WAP5 / WFDC2 / HE4 Protein

Sino Biological Inc. liefert Canine WAP5 / WFDC2 / HE4 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Canine WAP5 / WFDC2 / HE4 Protein lesen Sie bitte: http://www.sinobiological.com/WAP5-WFDC2-HE4-Protein-g-10191.html

Produkt-Information von WAP5 / WFDC2 / HE4 Protein

QC Testing von WAP5 / WFDC2 / HE4 Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: HE4 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gly 28
Molecular Mass	The recombinant canine WFDC2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 338 amino acids and has a predicted molecular mass of 37.3 kDa. The apparent molecular mass of the protein is approximately 48 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von WAP5 / WFDC2 / HE4 Protein

Verwandte Produkte & Themen von WAP5 / WFDC2 / HE4 Protein

Beschreibung von WAP5 / WFDC2 / HE4 Protein

WAP four-disulfide core domain protein 2, also known as Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2 and HE4, is a secreted protein which contains two WAP domains. WFDC2 / HE4 is a member of a family of stable 4-disulfide core proteins that are secreted at high levels. It is expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. It is highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. WFDC2 may be a component of the innate immune defences of the lung, nasal and oral cavities and suggest that WFDC2 functions in concert with related WAP domain containing proteins in epithelial host defence. WFDC2 re-expression in lung carcinomas may prove to be associated with tumour type and should be studied in further detail. Mammary gland expression of tammar WFDC2 during the course of lactation showed WFDC2 was elevated during pregnancy, reduced in early lactation and absent in mid-late lactation. WFDC2 / HE4 can undergo a complex series of alternative splicing events that can potentially yield five distinct WAP domain containing protein isoforms.

References

1. Bingle L. et al., 2002, Oncogene. 21 (17): 2768-73.
2. Hellstr m I. et al., 2003, Cancer Res. 63 (13): 3695-700.
3. Bingle L. et al., 2006, Respir Res. 7: 61.
4. Galgano MT. et al., 2006, Mod Pathol.19?(6): 847-53.
5. Sharp JA. et al., 2007, Evol Dev. 9 (4): 378-92.