Mouse IFNB1 / IFN-beta / Interferon beta Protein

26.04.2013

Sino Biological Inc. liefert Mouse IFNB1 / IFN-beta / Interferon beta Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse IFNB1 / IFN-beta / Interferon beta Protein lesen Sie bitte: http://www.sinobiological.com/IFNB1-IFN-beta-Interferon-beta-Protein-a-2619.html

Produkt-Information von IFNB1 / IFN-beta / Interferon beta Protein

Synonym	IFNB1
Protein Construction	A DNA sequence encoding the mouse IFNB1 (P01575) (Met 1-Asn 182) was fused with five amino acids (DDDDK) at the C- terminus was expressed and purified.
Source	Mouse
Expression Host	Human Cells

QC Testing von IFNB1 / IFN-beta / Interferon beta Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: IFNB1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Val 19
Molecular Mass	The recombinant mouse IFNB1 consists of 166 amino acids and has a calculated molecular mass of 20.3 kDa. The recombinant protein migrates as an approximately 30 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von IFNB1 / IFN-beta / Interferon beta Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von IFNB1 / IFN-beta / Interferon beta Protein

Interferon beta 1(IFN beta1) or IFNB1 is one type of IFN beta proteins that is a member of the Interferon type I family. Interferon beta 1(IFN beta1) or IFNB1 is produced in large quantities by fibroblasts and binds to a specific cell surface receptor complex known as the IFN alpha receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains as other members of IFN1 famlily do. The induction of interferon beta (IFNB1) is a key event in the antiviral immune response. It has shown that treatment with IFN beta affects NK cell cycle without altering NK cell apoptosis in MS patients. Treated with IFN beta alone or in combination with low-dose prednisolone displayed increased proportion of all NK cell subsets in the active phase of the cell cycle. There was no difference in NK cell apoptosis markers. Synthetic interferons (IFNs) are used in the treatment of several types of cancer. It has also been proved that apoptosis was decreased by IFN treatment, whereas inhibition of proliferation is caused by cell cycle arrest in late S-phase.

References

Sanvito L. et al., 2011, J Neuroimmunol. 236 (1-2) : 111-7.
Erdmann J. et al., 2011, J Interferon Cytokine Res. 31 (5): 451-8.
Biron CA. et al., 2002, Curr Top Microbiol Immunol. 263: 7-27.