Mouse ICAM2 / CD102 Protein

20.05.2013

Sino Biological Inc. liefert Mouse ICAM2 / CD102 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse ICAM2 / CD102 Protein lesen Sie bitte: http://www.sinobiological.com/ICAM-2-CD102-Protein-Antibody-a-321.html

Produkt-Information von ICAM2 / CD102 Protein

Synonym	ICAM2, CD102
Protein Construction	A DNA sequence encoding the mouse ICAM2 (NP_034624.1) (Met 1-Gln 222)was expressed with six amino acids (LEVLFQ) at the C- terminus.
Source	Mouse
Expression Host	Human Cells

QC Testing von ICAM2 / CD102 Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE ICAM2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ser 20
Molecular Mass	The recombinant mouse ICAM2 consists of 210 amino acids and has a calculated molecular mass of 23.6 kDa. The recombinant protein migrates as an approximately 38-42 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von ICAM2 / CD102 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von ICAM2 / CD102 Protein

Intercellular adhesion molecule 2, also known as ICAM-2 and CD102, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and ICAM family. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). It is a type I transmembrane glycoprotein with two Ig-like C2-type domains, and binds to the leukocyte integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). ICAM2 is mainly expressed on vascular endothelial and hematopoietic cells. Interactions of ICAM2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocyte with other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity and migration, lymphocyte recirculation, etc. ICAM2 may also play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion.

References

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