Mouse CTSS / Cathepsin-S Protein (His Tag)

Produkt-Information von CTSS / Cathepsin-S Protein

QC Testing von CTSS / Cathepsin-S Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: CTSS / Cathepsin-S protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Val 18
Molecular Mass	The recombinant mouse CTSS consists of 334 amino acids and predicts a molecular mass of 37.6 KDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmCTSS is approximately 33-38 KDa.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CTSS / Cathepsin-S Protein

Verwandte Produkte & Themen von CTSS / Cathepsin-S Protein

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>Cathepsin Family>>Cathepsin S/CTSS

Cancer>>Angiogenesis>>Cathepsin Family>>Cathepsin S/CTSS

Immunology>>Innate Immunity>>Lysosomal Enzyme>>Cathepsin Family>>Cathepsin S/CTSS

Beschreibung von CTSS / Cathepsin-S Protein

Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer's disease (AD) and Down Syndrome (DS).

References

1. Wiederanders B. 1992, J Biol Chem. 267: 13708-13.
2. Shi GP. et al., 1994, J Biol Chem. 269: 11530-6.
3. Lemere CA. 1995, Am J Pathol. 146: 848-60.

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