Mouse NLGN1 / Neuroligin-1 Protein (His Tag)

Produkt-Information von NLGN1 / Neuroligin-1 Protein

NLGN1 / Neuroligin-1 Protein QC Testing

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: NLGN1 / Neuroligin-1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 46
Molecular Mass	The recombinant mouse NLGN1 consists of 671 amino acids and predicts a molecular mass of 73.5 KDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmNLGN1 is approximately 100-110 KDa as a result of glycosylation.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von NLGN1 / Neuroligin-1 Protein

Verwandte Produkte & Themen von NLGN1 / Neuroligin-1 Protein

Neuroscience>>Synaptic Protein>>Neuroligin 1/NLGN1

Beschreibung von NLGN1 / Neuroligin-1 Protein

Neuroligin-1, also known as NLGN1, is a single-pass type I  membrane protein which belongs to the type-B carboxylesterase / lipase family. Neuroligins are cell-adhesion molecules located at the postsynaptic side of the synapse. Neuroligins interact with beta-neurexins and this interaction is involved in the formation of functional synapses. Neurexins and neuroligins are cell adhesion molecules present in excitatory and inhibitory synapses, and they are required for correct neuron network function. These proteins are found at the presynaptic and postsynaptic membranes. Neurexins and neurologins have an essential role in synaptic transmission. Altered neuronal connections during the development of the human nervous system could constitute the basis of the etiology of numerous cases of autism spectrum disorders. Neuroligin-1 / NLGN1 is a neuronal cell surface protein which is involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Neuroligin-1 / NLGN1 seems to play role in formation or maintenance of synaptic junctions. It triggers the de novo formation of presynaptic structures and may be involved in specification of excitatory synapses.

References

1. Meins,M. et al., 2005, Am J Med Genet A.  132A (1): 84-9.
2. Ylisaukko-oja,T. et al., 2005, Eur J Hum Genet. 13 (12): 1285-92.
3. Kelai,S. et al., 2008, Neuroreport. 19 (7): 751-5.
4. Calahorro,F. et al., 2009, J Vis Exp (34).

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