Mouse CSNK2A1 / CK2A1 Protein (GST Tag)

Produkt-Information von CSNK2A1 / CK2A1 Protein

CSNK2A1 / CK2A1 Protein QC Testing

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: CSNK2A1 / CK2A1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The secreted recombinant mouse CSNK2A1/GST chimera consists of 628 amino acids and has a calculated molecular mass of 72.9 kDa. The recombinant protein migrates as an approximately 65 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of 20mM Tris,500mM NaCl, pH 8.0, 10% gly. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CSNK2A1 / CK2A1 Protein

Verwandte Produkte & Themen von CSNK2A1 / CK2A1 Protein

Enzyme>>Protein Kinase>>Intracellular Kinase>>CSNK2A1

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>CSNK2A1

Stem Cell>>Wnt Signaling Pathway>>Non-Canonical Wnt Pathway>>CSNK2A1

Neuroscience>>Axon Guidance>>Wnt Signaling Pathway>>CSNK2A1

Beschreibung von CSNK2A1 / CK2A1 Protein

Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser/Thr protein kinase family and CK2 subfamily. Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. This kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. Three transcript variants encoding two different proteins have been found. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains of CSNK2A1 contain the catalytic site. It participates in Wnt signaling. CSNK2A1 is a tetramer composed of an alpha chain, an alpha' and two beta chains. It is also a component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. It interacts with RNPS1 as well.

References

1. Keller DM. et al., 2001, Mol Cell. 7: 283-92.
2. Sayed M. et al., 2000, J Biol Chem. 275 (22): 16569-73.
3. Kristensen. et al., 2004, FEBS Lett (Netherlands). 569 (1-3): 217-23.
4. Trembley JH. et al., 2005, Mol Cell Biol. 25:1446-57.
5. Adachi A. et al., 2009, Genes Cells. 14 (3): 355-69.

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