Mouse MAPK1 / ERK2 Protein (GST Tag)

Produkt-Information von MAPK1 / ERK2 Protein

QC Testing von MAPK1 / ERK2 Protein

Purity	> 96 % as determined by SDS-PAGE	SDS-PAGE: MAPK1 / ERK2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant mouse MAPK1/GST chimera consists of 595 amino acids and has a calculated molecular mass of 69.1 kDa. The recombinant protein migrates as an approximately 60 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of 20mM Tris, 500mM NaCl, pH 8.0, 10% gly. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von MAPK1 / ERK2 Protein

Verwandte Produkte & Themen von MAPK1 / ERK2 Protein

Enzyme>>Protein Kinase>>Intracellular Kinase>>Mitogen-Activated Protein Kinase (MAPK)>>ERK2/MAPK1/MAPK2

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>Mitogen-Activated Protein Kinase (MAPK)>>ERK2/MAPK1/MAPK2

Beschreibung von MAPK1 / ERK2 Protein

Mitogen-activated protein kinase 1, also known as Extracellular signal-regulated kinase 2, ERK-2, and MAPK1, is a member of the protein kinase superfamily and MAP kinase subfamily. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MKP-3 is a dual specificity phosphatase exclusively specific to MAPK1 for its substrate recognition and dephosphorylating activity. The activation of MAPK1 requires its phosphorylation by upstream kinases. Upon activation, MAPK1 translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. MAPK1 is involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. MAPK1 acts as a transcriptional repressor which represses the expression of interferon gamma-induced genes. Transcriptional activity is independent of kinase activity.

References

1. Formstecher E. et al., 2001,Dev Cell. 1 (2): 239-50.
2. Xu Be. et al., 2001, J Biol Chem. 276 (28): 26509-15.
3. Slack DN. et al., 2001, J Biol Chem. 276 (19): 16491-500.
4. Calvisi DF. et al., 2008, Cancer Res. 68 (11): 4192-200.

Sino Biological Inc. liefert Mouse MAPK1 / ERK2 Protein (GST Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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