Mouse AIMP1 / EMAP2 / SCYE1 Protein (Native)

Sino Biological Inc. liefert Mouse AIMP1 / EMAP2 / SCYE1 Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse AIMP1 / EMAP2 / SCYE1 Protein (Native) lesen Sie bitte: http://www.sinobiological.com/AIMP1-EMAP2-SCYE1-Protein-g-9874.html

Produkt-Information von AIMP1 / EMAP2 / SCYE1 Protein

QC Testing von AIMP1 / EMAP2 / SCYE1 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: AIMP1 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant mouse SCYE1 consists of  166 amino acids and predicts a molecular mass of 18 KDa. It migrates as an approximately 19 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von AIMP1 / EMAP2 / SCYE1 Protein

Verwandte Produkte & Themen von AIMP1 / EMAP2 / SCYE1 Protein

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>AIMP1/EMAP II

Beschreibung von AIMP1 / EMAP2 / SCYE1 Protein

Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, also known as Multisynthase complex auxiliary component p43, Endothelial monocyte-activating polypeptide II, AIMP1, EMAP2 and SCYE1, is a nucleus protein which contains one tRNA-binding domain. AIMP1 is a non-catalytic component of the multisynthase complex. AIMP1 negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. AIMP1 is involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. AIMP1 stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. It binds tRNA and possesses inflammatory cytokine activity. It promotes dermal fibroblast proliferation and wound repair and regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. AIMP1 plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations and induces maturation of dendritic cells and monocyte cell adhesion. AIMP1 modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.

References

1. Park S.G. et al., 1999,J Biol Chem. 274: 16673-6.
2. Shalak V. et al., 2001, J Biol Chem. 276: 23769-76.
3. Park S.G. et al., 2002,J Biol Chem. 277: 45243-8.
4. Park H. et al., 2002,J Leukoc Biol. 71: 223-30.
5. Tandle A.T. et al., 2009, Exp Cell Res. 315: 1850-9.