Mouse GPNMB / Osteoactivin Protein (His Tag)

Sino Biological Inc. liefert Mouse GPNMB / Osteoactivin Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von GPNMB / Osteoactivin Protein

GPNMB / Osteoactivin Protein QC Testing

Purity	>90% as determined by SDS-PAGE	SDS-PAGE: GPNMB protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Lys 23
Molecular Mass	The recombinant mouse GPNMB comprises 490 amino acids and has a predicted molecular mass of 54.9 kDa. The apparent molecular mass of the protein is approximately 96 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von GPNMB / Osteoactivin Protein

Verwandte Produkte & Themen von GPNMB / Osteoactivin Protein

Cancer>>Cancer Biomarkers>>GPNMB/Osteoactivin

Beschreibung von GPNMB / Osteoactivin Protein

GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteoclasts, macrophages, dendritic cells, and tumor cells. It is suggested to influence osteoblast maturation, cell adhesion and migration. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages. Osteoactivin is expressed at high levels in normal and inflammatory liver macrophages suggesting a significant role in acute liver injury. The early-phase upregulation of Osteoactivin expression in the tubular epithelium in response to renal injury might play a role in triggering renal interstitial fibrosis via activation of matrix metalloproteinase expression and collagen remodeling in rats. Osteoactivin as a protein that is expressed in aggressive human breast cancers and is capable of promoting breast cancer metastasis to bone.

References

1. Pahl MV. et al., 2010, Clin J Am Soc Nephrol. 5 (1): 56-61.
2. Abdelmagid SM. et al., 2008, Exp Cell Res. 314 (13): 2334-51.
3. Haralanova-Ilieva B. et al., 2005, J Hepatol. 242 (4): 565-72.
4. Abdelmagid SM. et al., 2007, J Cell Physiol. 210 (1): 26-37.
5. Furochi H. et al., 2007, J Med Invest. 54 (3-4): 248-54.