Mouse CD24 / Ly-52 / CD24A Protein

Sino Biological Inc. liefert Mouse CD24 / Ly-52 / CD24A Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von CD24 / Ly-52 / CD24A Protein

QC Testing von CD24 / Ly-52 / CD24A Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: CD24 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Asn 27
Molecular Mass	The recombinant mouse CD24 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 267 amino acids and has a predicted molecular mass of 29.7 kDa. The apparent molecular mass of the protein is approximately 48-52 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD24 / Ly-52 / CD24A Protein

Verwandte Produkte & Themen von CD24 / Ly-52 / CD24A Protein

Cancer>>Cancer Biomarkers>> CD24

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD24

Beschreibung von CD24 / Ly-52 / CD24A Protein

Signal transducer CD24, also known as small cell lung carcinoma cluster 4 antigen, CD24 and CD24A, is a cell membrane protein which belongs to the?CD24 family. It is expressed in a number of B-cell lines including P32/SH and Namalwa. It is also expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. CD24 modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. CD24 promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS). A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens. CD24 may act as a genetic modifier for susceptibility and progression of multiple sclerosis (MS) in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface.

References

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3. Zarn JA. et al., 1996, Biochem Biophys Res Commun. 225: 384-91.
4. Suzuki T. et al., 2001, J Immunol. 166: 5567-77.
5. Zhou Q. et al., 2003, Proc Natl Acad Sci. 100: 15041-6.