MAPT / Tau Protein (His Tag)

16.04.2013

Sino Biological Inc. liefert MAPT / Tau Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über MAPT / Tau Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/MAPT-PHF-tau-Protein-Antibody-a-5868.html

Produkt-Information von MAPT / Tau Protein

Synonym	MAPT, MAPTL, MTBT1, TAU
Protein Construction	A DNA sequence encoding the mature form of human MAPT (NP_058525.1) (Ala2-Leu352) was expressed with a polyhistide tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von MAPT / Tau Protein

Purity	> 85% as determined by SDS-PAGE	SDS-PAGE: MAPT protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human MAPT consists of 367 amino acids and predicts a molecular mass of 38.7 KDa. It migrates as an approximately 40-50 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von MAPT / Tau Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von MAPT / Tau Protein

MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development - possibly because of compensation in tau deficiency by other MAPs.

References

Harada A. et al., 1994, Nature. 369 (6480): 488-91.
Weingarten MD. et al., 1975, Proc Natl Acad Sci. 72 (5): 1858-62.
Goedert M. et al., 1989, Neuron. 3 (4): 519-26.

MAPT (PHF-tau) related areas, pathways, and other information