LAMP-1 / CD107a / LAMP1 Antikörper ( FITC )

Produkt-Information von LAMP-1 / CD107a / LAMP1 Antikörper

Usage Guide von LAMP-1 / CD107a / LAMP1 Antikörper

Specificity	Human LAMP-1 / CD107a / LAMP1
	No cross-reactivity in ELISA with Human cell lysate (293 cell line)
Flow Cytometry	The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with FITC Mouse anti-LAMP1. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. Flow cytometric analysis of Human LAMP1 (CD107a) expression in Jurkat cells. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human LAMP1 in WB. Using a DAB detection system, the detection limit for Human LAMP1 is approximately 2 ng/lane under non-reducing conditions. Use of this antibody under reducing conditions is not recommended.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃- 8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Verwandte Produkte & Themen von LAMP-1 / CD107a / LAMP1 Antikörper

Cancer>>Cancer Stem Cell (CSC)>>LAMP-1/CD107a

Immunology>>Innate Immunity>>Lysosomal Enzyme>>LAMP-1/CD107a

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>LAMP-1/CD107a

Immunology>>Cluster of Differentiation>>Other>>LAMP-1/CD107a

Hintergrund von LAMP-1 / CD107a / LAMP1 Antikörper

Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein which belongs to theLAMP family. CD107a is expressed largely in the endosome-lysosome membranes of cells, but is also found on the plasma membrane (1-2% of total LAMP1). LAMP1 has been implicated in a variety of cellular functions, including cancer metastasis. It has been proposed LAMP1 serves as a therapeutic agent for some cancers, as well as a marker for lysosomal storage disorders and different cell types such as cytotoxic T cells. LAMP2, also known as CD107b, may also play a role in tumor cell metastasis and functions in the protection, maintenance, and adhesion of the lysosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.

References

1. Schleutker, J. et al., 1992,Hum. Genet.88 (1): 95-7.
2. Kannan, K.et al., 1996,Cell Immunol. 171 (1):10-9.
3. Chang MH, et al., 2003,J. Biol. Regul.Homeost. Agents.16 (2): 147-51.
4. Parkinson-Lawrence, EJ. et al., 2005, Cell Immunol. 236 (1-2): 161-6.

Sino Biological Inc. liefert LAMP-1 / CD107a / LAMP1 Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über LAMP-1 / CD107a / LAMP1 Antikörper ( FITC ) lesen Sie bitte: http://www.sinobiological.com/LAMP-1-CD107a-LAMP1-Antibody-g-8817.html