CD45 Antikörper ( FITC )

Produkt-Information von CD45 Antikörkper

Usage Guide von CD45 Antikörper

Specificity	Human CD45
	No cross-reactivity in WB and ELISA with Human cell lysate (293 cell line)
Flow Cytometry	The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable lymphocytes. Profile of peripheral blood lymphocytes analyzed by flow cytometry. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃- 8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

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As a member of the protein tyrosine phosphatase (PTP) family, CD45 is a transmembrane glycoprotein existing as four isoforms derived from alternative spliced transcripts. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and is expressed at high levels on the cell surface of all nucleated hematopoietic cells and their precursors. CD45 has been shown to be an essential regulator of T-and B-cell antigen receptor signaling. It exerts actions either by modulating the phosphorylation state of the antigen receptor subunits as a component associated with antigen receptors, or through Src-related pathways by activating various Src family kinases, and thus regulates a variety of critical cellular processes. In addition, binding of CD45-associated protein (AP) converts inactive CD45 dimer to active monomers.

References

1. Justement, L.B. et al., 1991, Science. 252: 1839-1842.
2. McKenney, D.W. et al., 1995, J. Biol. Chem. 270: 24949-24954.
3. Qian, D. et al., 1997, Curr. Opin.Cell. Biol. 9: 205-212.
4. Koretzky, G.A. et al., 1990, Nature. 346: 355-365.
5. Burns, C.M. et al., 1994, J. Biol. Chem. 269: 13594-13600.
6. Takeda, A. et al., 2004, Blood. 103: 3440-3447.

Sino Biological Inc. liefert CD45 Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CD45 Antikörper ( FITC ) lesen Sie bitte: http://www.sinobiological.com/CD45-Antibody-g-8816.html