Jumping Translocation Breakpoint / JTB Protein

Sino Biological Inc. liefert Jumping Translocation Breakpoint / JTB Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Jumping Translocation Breakpoint / JTB Protein lesen Sie bitte: http://www.sinobiological.com/Jumping-Translocation-Breakpoint-JTB-Protein-g-11838.html

Produkt-Information von Jumping Translocation Breakpoint / JTB Protein

QC Testing von Jumping Translocation Breakpoint / JTB Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: JTB protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 31
Molecular Mass	The recombinant human JTBm/Fc is a disulfide-linked homodimer. The reduced monomer comprises 309 amino acids and has a predicted molecular mass of 34.7 kDa. The apparent molecular mass of the protein is approximately 38 in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von Jumping Translocation Breakpoint / JTB Protein

Verwandte Produkte & Theme von Jumping Translocation Breakpoint / JTB Protein

Jumping Translocation Breakpoint / JTB Protein

Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomalsegments jumping to various telomeres. JTB is expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. It is required for normal cytokinesis during mitosis. JTB plays a role in the regulation of cell proliferation. It may be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.

References

1. Hatakeyama S. et al., 1999, Oncogene. 18 (12): 2085-90.
2. Platica O. et al., 2000, Int J Oncol. 16 (5): 1055-61.
3. Erhard DS. et al., 2004, Genome Res. 14 (10B): 2121-7.