Cynomolgus CD160 Protein (His Tag)

24.05.2013

Sino Biological Inc. liefert Cynomolgus CD160 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus CD160 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/CD160-Protein-a-1523.html

Produkt-Information von CD160 Protein

Synonym	CD160
Protein Construction	A DNA sequence encoding the cynomolgus CD160 (Met1-Leu158) was expressed with a polyhistidine tag at the C-terminus.
Source	Cynomolgus
Expression Host	Human Cells

QC Testing von CD160 Protein

Purity	(70+22.5)% as determined by SDS-PAGE	SDS-PAGE: CD160 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gly 25
Molecular Mass	The recombinant cynomolgus CD160 comprises 145 amino acids and has a calculated molecular mass of 16.3 KDa. The apparent molecular mass of it is approximately 25 and 22 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von CD160 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CD160 Protein

CD160 antigen, also known as Natural killer cell receptor BY55 and CD160, is a cell membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56(dim)CD16(+) peripheral blood NK subset. CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD160 is expressed in spleen, peripheral blood, and small intestine. Expression of CD160 is restricted to functional NK and T cytotoxic lymphocytes. CD160 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD160+ T cells isolated from inflammatory skin lesions. Unique CD4+ CD160+ lymphocyte subset may play a role in the pathogenesis of skin inflammation. Activated NK lymphocytes release a soluble form of CD160 that functionally impairs the MHC-I-specific cytotoxic CD8(+) T lymphocyte responsiveness.

References

Barakonyi A. et al., 2004, J Immunol.173 (9): 5349-54.
Rabot M. et al., 2006, Transpl Immunol. 17 (1): 36-8.
Abecassis S. et al., 2007, J Invest Dermatol. 127?(5): 1161-6.
Giustiniani J.?et al., 2007, J Immunol. 178 (3): 1293-300.