Interferon beta / IFN-beta / IFNB Protein (Native)

Sino Biological Inc. liefert Interferon beta / IFN-beta / IFNB Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von Interferon beta / IFN-beta / IFNB Protein

QC Testing von Interferon beta / IFN-beta / IFNB Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: TNFB protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met 22
Molecular Mass	The recombinant human IFNβ  consists of  166 amino acids and predicts a molecular mass of 20 KDa. It migrates as an approximately 20-23 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 50mM Hepes, PH 7.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide VON Interferon beta / IFN-beta / IFNB Protein

Verwandte Produkte & Themen von Interferon beta / IFN-beta / IFNB Protein

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IFN beta/IFNB

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-10/Interferon Family>>IFN beta/IFNB

Beschreibung von Interferon beta / IFN-beta / IFNB Protein

Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily, and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, parasites and tumor cells. IFNs are produced by a wide variety of cells in response to the presence of dsRNA, a key indicator of viral infection via a pattern recognition receptor of the innate immune system Toll Like Receptor 3 (TLR 3), and in turn assists the immune response by inhibiting viral replication within host cells, activating natural killer cells and macrophages, increasing antigen presentation to lymphocytes, and inducing the resistance of host cells to viral infection. There are three major classes of IFNs according to the receptor type through which they signal, and the type I IFNs bind to a specific receptor complex known as the IFN-α receptor (IFNAR) consisting of IFNAR1 and IFNAR2 chains. The type I  IFNs present in humans are IFN-α, IFN-β and IFN-ω and IFN-β is produced by fibroblast. In addition to the common antiviral activity, IFN-β also induces increased production of the p53 gene product which promotes apoptosis, and thus has therapeutic effect against certain cancers. Furthermore, IFN-β might play a beneficial role in the development of a chronic progressive CNS inflammation.

References

1. Morikawa K. et al., 1987, J Immunol. 139: 761-6.
2. Sato K. et al., 2001, Eur J Immunol. 31: 3188-46.
3. Takaoka A. et al., 2003, Nature. 424: 516-23.
4. Improta T. et al., 1997, Cytokine. 9: 383-93.
5. Teige I. et al., 2006, J Immunol. 177: 3542-53.