RTN4R / NOGOR Protein (His Tag)

Sino Biological Inc. liefert RTN4R / NOGOR Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über RTN4R / NOGOR Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/RTN4R-NOGOR-Protein-g-10022.html

Produkt-Information von RTN4R / NOGOR Protein

QC Testing von RTN4R / NOGOR Protein

Purity	> 90% as determined by SDS-PAGE	SDS-PAGE: RTN4R protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Cys 27
Molecular Mass	The recombinant human RTN4R consists of  433 amino acids and predicts a molecular mass of 46.8 KDa. It migrates as an approximately 60 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von RTN4R / NOGOR Protein

Verwandte Produkte & Themen von RTN4R / NOGOR Protein

Neuroscience>>Axon Guidance>>Other Axon Guidance Proteins>>Nogo R/RTN4R

Stem Cell>>Neural Stem Cell (NSC)>>Glial Cell Markers>>Nogo R/RTN4R

Beschreibung von RTN4R / NOGOR Protein

Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 10 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions.

References

1. Wang X. et al., 2006, Ann Neurol. 60 (5): 540-9.
2. Wang YZ. et al., 2006, Neuroreport. 17 (6): 605-9.
3. Zhu HY. et al., 2007, Hum Pathol. 38 (3): 426-34.?
4. David S. et al., 2008, Trends Neurosci. 31 (5): 221-6.
5. Jiang W. et al., 2009, Transl Res. 154 (1): 40-8.
6. Zhang L. et al., 2009, J Neurosci, 9 (19): 6348-52.