MAG / GMA Protein

Sino Biological Inc. liefert MAG / GMA Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über MAG / GMA Protein lesen Sie bitte: http://www.sinobiological.com/MAG-GMA-Protein-g-10026.html

Produkt-Information von MAG / GMA Protein

QC Testing von MAG / GMA Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: MAG protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gly 20
Molecular Mass	The recombinant human MAG/Fc is a disulfide-linked homodimer. The reduced monomer comprises 738 amino acids and has a predicted molecular mass of 81.7 kDa. The apparent molecular mass of the protein is approximately 113 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von MAG / GMA Protein

Verwandte Produkte & Themen von MAG / GMA Protein

Adhesion Molecule>>Lectin>>MAG/Siglec-4

Beschreibung von MAG / GMA Protein

The myelin-associated glycoprotein (MAG) is a transmembrane glycoprotein of 100kDa localized in myelin sheaths of periaxonal Schwann cell and oligodendroglial membranes where it functions in glia-axon interactions. MAG contains five immunoglobulin-like domains and belongs to the sialic-acid-binding subgroup of the Ig superfamily. It appears to function both as a receptor for an axonal signal that promotes the differentiation, maintenance and survival of oligodendrocytes and as a ligand for an axonal receptor that is needed for the maintence of myelinated axons. MAG contains a carbohydrate epitope shared with other glycoconjugates that is a target antigen in autoimmune peripheral neuropathy associated with IgM gammopathy and has been implicated in a dying back oligodendrogliopathy in multiple sclerosis. MAG is considered as a transmembrane protein of both CNS and PNS myelin and it strongly inhibits neurite outgrowth in both developing cerebellar and adult dosal root ganglion neurons. In contrast, MAG promotes neurite outgrowth from newborn DRG neurons. Thus, MAG may be responsible for the lack of CNS nerve regeneration and may influce both temporally and spatially regeneration in the PNS.

References

1. Quarles RH. 2007, J Neurochem. 100 (6): 1431-48.
2. Mukhopadhyay G. et al., 1994, Neuron. 13 (3): 757-67.
3. Barton DE. et al., 1987, Genomics. 1 (2): 107-12.