ING4 Protein (His Tag)

06.05.2013

Sino Biological Inc. liefert ING4 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über ING4 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/ING4-Protein-Antibody-a-5908.html

Produkt-Inromation von ING4 Protein

Synonym	ING4
Protein Construction	A DNA sequence encoding the mature form of human ING4 (Q9UNL4-1) (Met1-Lys249) was expressed with a polyhistidine tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von ING4 Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: ING4 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human ING4 consists of 264 amino acids and predicts a molecular mass of 30.4 KDa. It migrates as an approximately 31 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von ING4 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von ING4 Protein

ING4 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. ING4 contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. ING4 protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. ING4 is a component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. ING4 may also inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation.

References

Shiseki M. et al., 2003, Cancer Res. 63 (10): 2373-8.
Garkavtsev. et al., 2004, Nature. 428 (6980): 328-32.
Tsai. et al., 2008, Exp Cell Res. 314 (17): 3130-41.