IL23R / IL23 Receptor Protein

04.03.2013

Sino Biological Inc. liefert IL23R / IL23 Receptor Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über IL23R / IL23 Receptor Protein lesen Sie bitte: http://www.sinobiological.com/IL23R-IL23-Receptor-Protein-g-10541.html

Produkt-Information von IL23R / IL23 Receptor Protein

Synonym	IL23R
Protein Construction	A DNA sequence encoding the human IL23R (Met1-Asp353) was expressed with the Fc region of human IgG1 at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von IL23R / IL23 Receptor Protein

Purity	(45+17.3+30.1) % as determined by SDS-PAGE	SDS-PAGE: IL23R protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gly 24
Molecular Mass	The recombinant human IL23R /Fc is a disulfide-linked homodimer. The reduced monomer comprises 571 amino acids and has a predicted molecular mass of 64.9 kDa. The apparent molecular mass of the protein is approximately 92, 58 and 37 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL23R / IL23 Receptor Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von IL23R / IL23 Receptor Protein

IL23R, also known as IL23Receptor, is a member of the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.

References

Duerr RH. et al., 2006, Science. 314 (5804): 1461-3.
Cargill M. et al., 2007, Am J Hum Genet. 80 (2): 273-90.
Dubinsky MC. et al., 2007, Inflamm Bowel Dis. 13 (5): 511-5.
Tremelling M. et al., 2007, Gastroenterology. 132 (5): 1657-64.

Cytokine