IL1F6 / IL36 (aa 6-158) Protein

05.09.2012

Produkt-Information von IL1F6 / IL36 Protein

Synonym	FIL1E, IL1E, IL1F6, IL1F6
Protein Construction	A DNA sequence encoding the human IL1F6(Q9UHA7) (Ala6-Phe158) was expressed and purified, with two additional amino acids (Gly & Pro) at the N-terminus.
Source	Human
Expression Host	E.coli

IL1F6 / IL36 Protein QC Testing

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: IL1F6 / IL36 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gly
Molecular Mass	The recombinant human IL1F6 consists of 155 amino acids and predicts a molecular mass of 17 .2 KDa. It migrates as an approximately 18 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL1F6 / IL36 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von IL1F6 / IL36 Protein

Related Areas:

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family>>IL-1F6/IL1F6

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-1F6/IL1F6	Human	IL1F6 / IL36A Protein, Recombinant, Native	10607-HNAE
IL-1F6/IL1F6	Human	IL1F6 / IL36A Protein, Recombinant	10607-H07E1
IL-1F6/IL1F6	Human	IL1F6 / IL36 (aa 6-158) Protein, Recombinant	10607-HNCE1
IL-1F6/IL1F6	Mouse	IL-1F6/IL-1 epsilon Protein, Recombinant, Native	50095-HNAE

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IL-1F6/IL1F6	WB, ELISA	IL1F6 / IL36A Antibody	10607-RP01
Mouse IL-1F6/IL1F6	WB, ELISA	IL-1F6 Antibody (Antigen Affinity Purified)	50095-RP02

Beschreibung von IL1F6 / IL36 Protein

Interleukin-1 family member 6, also known as IL-1F6, FIL1 epsilon, Interleukin-1 epsilon, IL-1 epsilon, IL1F6 and FIL1E, is a secreted protein which belongs to the IL-1 family. IL-1F6 is a new IL-1 family member. IL1F6 / FIL1E is expressed in immune system, fetal brain and adipose tissue and that IL-1F6 and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-1F6 inhibits PPARγ expression which may lead to reduced adipocyte differentiation suggesting metabolic effects of this cytokine.. IL1F6 / FIL1E, along with IL-36β / IL-1F8 and IL-36γ / IL-1F9, has been shown to act as an agonist by activating the pathway involving NF-κB and MAPK in an IL-1 Rrp2 dependent manner. IL1F6 / FIL1E may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.

References

Smith DE. et al., 2000, J Biol Chem. 275: 1169-1175.
Dunn E. et al. 2001, Trends Immunol. 22-53.
Nicklin MJ. et al., 2002, Genomics. 79 (5): 718-25.
Blumberg H. et al., 2007, J Exp Med. 204 (11): 2603-14.
Dinarello C. et al., 2010, Nat Immunol. 11: 973.

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