ANGPTL4 / ANGPTL2 Protein

05.09.2012

Produkt-Information von ANGPTL4 / ANGPTL2 Protein

Synonym	ANGPTL4, ARP4, HFARP, PGAR
Protein Construction	A DNA sequence encoding the human ANGPTL4(Q9BY76) (Pro166-Ser406) was expressed ,with the fused Fc region of human IgG1 at the N-terminus.
Source	Human
Expression Host	Human Cells

ANGPTL4 / ANGPTL2 Protein QC Testing

Purity	> 92 % as determined by SDS-PAGE	SDS-PAGE: ANGPTL4 / ANGPTL2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant human ANGPTL4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 501 amino acids and has a predicted molecular mass of 55.5 kDa. The apparent molecular mass of the protein is approximately 65 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of Sterile 50 mM Tris-Citrate, 0.3 M NaCl, pH 6.5. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von ANGPTL4 / ANGPTL2 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von ANGPTL4 / ANGPTL2 Protein

ANGPTL4, also known as ANGPTL2, is a protein with hypoxia-induced expression in endothelial cells. It may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. ANGPTL4 is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). ANGPTL4 inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. It may act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. It may also exert a protective function on endothelial cells through an endocrine action.

References

Lichtenstein L. et al., 2010, Cell metabolism. 12 (6): 580-92.
Terada S. et al., 2011, Cancer Cell. 19 (3): 297-9.
Zhu PC. et al., 2011, Cancer Cell. 19 (3): 401-15.

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