IL17 / IL17A Protein (His Tag)

Produkt-Information von IL17 / IL17A Protein

QC Testing von IL17 / IL17A Protein

Purity	> 98 % as determined by SDS-PAGE	SDS-PAGE: IL17 / IL17A protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human human IL17A consists of  152 amino acids and predicts a molecular mass of 17.3 KDa. It migrates as an approximately 19 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of 20mM Tris, 500mM NaCl, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL17 / IL17A Protein

Verwandte Produkte & Themen von IL17 / IL17A Protein

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL17 / IL17a

Beschreibung von IL17 / IL17A Protein

IL17, also known as IL17a, is a member of the IL-17 family. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. Members of this family have a highly conserved C-terminus containing a cysteine-knot fold structure. Most IL-17 proteins are secreted as disulfide-linked dimers, with the exception of IL-17B, which is secreted as a non-covalent homodimer IL17 is a proinflammatory cytokine produced by activated T cells. It regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. IL17 also induces stromal cells to produce proinflammatory and hematopoietic cytokines. It enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.

References

1. Andoh A. et al., 2002, J Immunol. 169 (4): 1683-7.
2. Kotake S. et al., 1999, J Clin Invest. 103 (9): 1345-52.
3. Laan M. et al., 1999, J Immunol. 162 (4): 2347-52.
4. Shin HC. et al., 1999, Cytokine. 10 (11): 841-50.

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