IL-28B / IFN-lambda-3 Antikörper (Antigen Affinität reinigt)

15.03.2012

Produkt-Information von IL-28B / IFN-lambda-3 Antikörper

Immunogen	Recombinant Human IL-28B / IFN-lambda-3 protein (Catalog#11890-H08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human IL-28B / IFN-lambda-3 (rh IL-28B / IFN-lambda-3; Catalog#11890-H08H; NP_742151.2; Met 1-Val 196). IL-28B / IFN-lambda-3 specific IgG was purified by Human IL-28B / IFN-lambda-3 affinity chromatography.

IL-28B / IFN-lambda-3 Antikörper Usage Guide

Specificity	Human IL-28B / IFN-lambda-3
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human IL28B in WB. Using a DAB detection system, the detection limit for Human IL28B is approximately 0.5 ng/lane under non-reducing conditions and reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human IL28B. The detection limit for Human IL28B is approximately 0.039 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von IL-28B / IFN-lambda-3 Antikörper

Interleukin-28B, also known as IL-28B, Cytokine Zcyto22, Interferon lambda-3, Interferon lambda-4, Interleukin-28C, IL28B and IFNL3, is a secreted protein which belongs to theIL-28/IL-29 family. Interleukin-28B / IL28B is a cytokine with immunomodulatory activity. It up-regulates MHC class I antigen expression. Interleukin-28B / IL28B displays potent antiviral activity. It also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. IL28B contributes to viral resistance and is known to be upregulated by interferons and by RNA virus infection. Hepatitis C Virus (HCV) infection is spontaneously resolved in about 30% of acutely infected individuals. In those who progress to chronic hepatitis C, HCV therapy permanently eradicates infection in about 40% of cases. It has long been suspected that host genetic factors are key determinants for the control of HCV infection. Genetic variation in Interleukin-28B / IL28B is the strongest predictor for the control of HCV infection. Importantly, single nucleotide polymorphisms (SNPs) in IL28B strongly predicted both spontaneous and treatment-induced HCV recovery.

References

Sheppard P. et al., 2003, Nat. Immunol. 4: 63-8.
Li M.C.et al., 2006, Acta Pharmacol. Sin. 27: 453-9.
Gad H.H. et al., 2009, J. Biol. Chem. 284: 20869-75.
Suppiah,V. et al., 2009, Nat Genet41 (10): 1100-4.
Montes-Cano, M.A. et al., 2010,Hepatology. 52 (1): 33-7.

Sino Biological Inc. liefert IL-28B / IFN-lambda-3 Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über IL-28B / IFN-lambda-3 Antikörper (Antigen Affinität reinigt) lesen Sie bitte: http://www.sinobiological.com/IL-28B-IFN-lambda-3-Antibody-g-8290.html