CD80 / B7-1 Antikörper( FITC )

Produkt-Information von CD80 / B7-1 Antikörkper

Usage Guide von CD80 / B7-1 Antikörper

Specificity	Human CD80 / B7-1
Flow Cytometry	Cells should be Fc-blocked by treatment with 20 μg of human IgG/106 cells for 1 hour at 4 ℃ prior to staining, washed, then stained with FITC Mouse anti-B7-1 (CD80). Profile of anti-B7-1 (CD80) reactivity on U937 cells analyzed by flow cytometry. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃- 8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

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Hintergrund von CD80 / B7-1 Antikörper

The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. Binding of this protein with CTLA-4 is involved in down-regulation of immune response.Recent study has revealed that contacts between B and T helper cells mediated by CD80 provide negative signal for the proliferation and IgG secretion of normal B cells and B cell lymphomas. In addition, B7-1 also plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages.CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

References

1. Freeman, G.J. et al., 1991, J. Exp. Med. 174: 625-631.
2. Lanier, L.L. et al., 1995, J. Immunol. 154:97-105.
3. Suvas, S. et al., 2001, J. Biol. Chem. 277: 7766-7775.
4. Bhatia, S. et al., 2005, Proc. Natl. Acad. Sci. 102: 15569-15574.
5. Sigal, L.J. et al., 1998, J. Immunol. 161: 2740-2745.
6. Khan, N. et al., 2007, Int. Immunol. 19: 477-486.

Sino Biological Inc. liefert CD80 / B7-1 Antikörper( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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