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| Immunogen | Recombinant Human IL-16 protein (Catalog#10944-H07E) |
| Antibody Type | Mouse Monoclonal Antibody ( Mouse mAb Service Platform ) |
| Clone ID | 04 |
| Ig Type | Mouse IgG2a |
| Formulation | 0.2 μm filtered solution in PBS with 5% trehalose |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-16 (rh IL-16; Catalog#10944-H07E; AAC12732.1; Pro 2-Ser 130). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Specificity | Human IL-16 |
| No cross-reactivity in ELISA with E.coli cell lysate | |
| Western blot | This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human IL16 in WB. Using a DAB detection system, the detection limit for Human IL16 is approximately 4 ng/lane under non-reducing conditions and reducing conditions. |
| Direct ELISA | This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human IL16. The detection limit for Human IL16 is approximately 0.16 ng/well. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Interleukin-16, also known as Lymphocyte chemoattractant factor, LCF and IL16, is a secreted, cytoplasm and nucleus protein which contains 4PDZ (DHR) domains. Interleukin-16 / IL16 was originally described as a factor that could attract activated T cells in humans, it was previously called lymphocyte chemoattractant factor (LCF). Since then, this interleukin has been shown to recruit and activate many other cells expressing the CD4 molecule, including monocytes, eosinophils, and dendritic cells. The structure of Interleukin-16 / IL16 was determined following its cloning in 1994. Interleukin-16 / IL16 is produced as a precursor peptide (pro-IL-16) that requires processing by an enzyme called caspase-3 to become active. CD4 is the cell signaling receptor for mature IL-16. Interleukin-16 / IL16 is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. Interleukin-16 / IL16 is a cytokine that released by a variety of cells (including lymphocytes and some epithelial cells) that has been characterized as a chemoattractant for certain immune cells expressing the cell surface molecule CD4. The signaling process of Interleukin-16 / IL16 is mediated by CD4. It undergoes proteolytic processing, which is found to yield two functional proteins. Interleukin-16 / IL16 function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
Sino Biological Inc. liefert IL-16 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.
Weitere Informationen über IL-16 Antikörper lesen Sie bitte: http://www.sinobiological.com/IL-16-Antibody-g-9161.html
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