IBA1 / AIF1 Protein (His Tag)

15.03.2013

Sino Biological Inc. liefert IBA1 / AIF1 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über IBA1 / AIF1 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/IBA1-AIF1-Protein-g-10609.html

Produkt-Information von IBA1 / AIF1 Protein

Synonym	AIF1, G1, IBA1
Protein Construction	A DNA sequence encoding the mature form of human AIF1 (P55008-1) (Met1-Pro147) was expressed with a polyhistide tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von IBA1 / AIF1 Protein

Purity	> 85% as determined by SDS-PAGE	SDS-PAGE: IBA1 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human AIF1 consists of 162 amino acids and predicts a molecular mass of 18.5 KDa. It migrates as an approximately 18 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, 10% glycerol, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von IBA1 / AIF1 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von IBA1 / AIF1 Protein

AIF1, also known as IBA1, is an actin-binding protein. AIF1 is expressed selectively in human macrophage-like cell lines, and in a subset of CD68(+) macrophages in the interstitial and perivascular spaces of human heart allografts. It is expressed in macrophages and neutrophils. AIF1 enhances membrane ruffling and RAC activation. AIF1 enhances the actin-bundling activity of LCP1. It also enhances lymphocyte migration. AIF1 may play a role in macrophage activation and function. It binds calcium and plays a role in RAC signaling and in phagocytosis. It promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes.

References

Kelemen SE. et al., 2003, Circ Res. 92 (10): 1107-14.
Arvanitis DA. et al., 2005, J Cell Mol Med. 9 (1): 153-9.
Gerhard DS. et al., 2004, Genome Res. 14 (10B): 2121-7.