I-TAC / CXCL11 Protein (Native)

01.03.2013

Sino Biological Inc. liefert I-TAC / CXCL11 Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über I-TAC / CXCL11 Protein (Native) lesen Sie bitte: http://www.sinobiological.com/I-TAC-CXCL11-Protein-g-10534.html

Produkt-Information von I-TAC / CXCL11 Protein

Synonym	CXCL11, ITAC, SCYB11, SCYB9B
Protein Construction	A DNA sequence encoding the mature form of human CXCL11(O14625) (Phe22-Phe94) was expressed with an initial Met.
Source	Human
Expression Host	E.coli

QC Testing von I-TAC / CXCL11 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: I-TAC / CXCL11 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human CXCL11 consists of 73 amino acids and predicts a molecular mass of 8.3 KDa. It migrates as an approximately 9 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 40% acetonitrile, 1% TFA. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von I-TAC / CXCL11 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von I-TAC / CXCL11 Protein

I-TAC, also known as CXCL11, is a small cytokine belonging to the CXC chemokine family. It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. I-TAC is chemotactic for activated T cells. The CXCL11 gene is located on human chromosome 4 along with many other members of the CXC chemokine family. The I-TAC chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10.

References

Strausberg RL. et al., 2003, Proc Natl Acad Sci. 99 (26): 16899-903.
Rani MR. et al., 2002, J Biol Chem. 277 (41): 38456-61.
Salmaggi A. et al., 2003, J Interferon Cytokine Res. 22 (6): 631-40.

Cytokine

Chemokine