GGCT Protein (His Tag)

11.04.2013

Sino Biological Inc. liefert GGCT Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über GGCT Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/GGCT-Protein-Antibody-a-5775.html

Produkt-Information von GGCT Protein

Synonym	GGCT, C7orf24, CRF21
Protein Construction	A DNA sequence encoding the mature form of human GGCT (O75223-1) (Met1-Leu188) was expressed with a polyhistide tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von GGCT Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: GGCT protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human GGCT consists of 203 amino acids and predicts a molecular mass of 22.8 KDa. It migrates as an approximately 23-26 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von GGCT Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von GGCT Protein

GGCT belongs to the gamma-glutamylcyclotransferase family. It catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism. GGCT may play a significant role in glutathione homeostasis. GGCT also induces release of cytochrome c from mitochondria with resultant induction of apoptosis. Pseudogenes of GGCT gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

References

Wagner SA. et al., 2011, Mol Cell Proteomics. 10 (10): M111.013284.
Kim W. et al., 2011, Mol Cell. 44 (2): 325-40.
Amano T. et al., 2012, J Histochem Cytochem. 60 (1): 76-86.

GGCT related areas, pathways, and other information