Fractalkine / CX3CL1 Antikörper

Sino Biological Inc. liefert Fractalkine / CX3CL1 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Fractalkine / CX3CL1 Antikörper lesen Sie bitte: http://www.sinobiological.com/Fractalkine-CX3CL1-Antibody-g-10059.html

Produkt-Information von Fractalkine / CX3CL1 Antikörper

Usage Guide von Fractalkine / CX3CL1 Antikörper

Specificity	Human Fractalkine / CX3CL1
Flow Cytometry	Flow cytometric analysis of Human CX3CL1 expression in HeLa cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and stained with Purified Mouse anti-CX3CL1 (10636-MM12), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von Fractalkine / CX3CL1 Antikörper

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>Fractalkine/CX3CL1

Immunology>>Cytokine & Receptor>>Chemokine & Receptor>>Fractalkine/CX3CL1

Hintergrund von Fractalkine / CX3CL1 Antikörper

Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a large cytokine protein containing multiple domains and is the only known member of the CX3C chemokine family. It is also commonly known as fractalkine (in humans) and neurotactin (in mice). The polypeptide structure of CXC3L1 differs from the typical structure of other chemokines. Mature human CX3CL1 consists of a 76 aa residue chemokine domain, a 241 aa residue stalk region containing 17 degenerate mucin-like repeats, a 19 aa residue transmembrane segment and a 37 aa residue cytoplasmic domain. The extracellular domain of human CX3CL1 can be released, possibly by proteolysis at the dibasic cleavage site proximal to the membrane, to generate soluble CX3CL1. Soluble CX3CL1 potently chemoattracts T cells and monocytes, while the cell-bound CX3CL1 promotes strong adhesion of leukocytes to activated endothelial cells where it is primarily expressed. CX3CL1 elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1.

References

1. Bazan, J. F.,et al.,1997, Nature. 385: 640-644.
2. Imai,T. et al., 1997, Cell. 91: 521-530.
3. Nomiyama, H. et al., 1998, Cytogenet. Cell Genet. 81: 10-11.
4. Papadopoulos, E. et al., 1999, Eur. J. Immunol. 29 (8): 2551-2559.
5. Umehara, H. et al., 2004, Arterioscler. Thromb. Vasc. Biol. 24 (1): 34-40.

Primary Antibody Products