FGFR1OP / FOP Protein (GST Tag)

24.04.2013

Sino Biological Inc. liefert FGFR1OP / FOP Protein (GST Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über FGFR1OP / FOP Protein (GST Tag) lesen Sie bitte: http://www.sinobiological.com/FOP-FGFR1OP-Protein-Antibody-a-5845.html

Produkt-Information von FGFR1OP / FOP Protein

Synonym	FGFR1OP, FOP
Protein Construction	A DNA sequence encoding the human FGFR1OP ( Ala2- Ala379) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Source	Human
Expression Host	Baculovirus-Insect cells

QC Testing von FGFR1OP / FOP Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: FGFR1OP protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The secreted recombinant human FGFR1OP consists of 615 amino acids and predicts a molecular mass of 68.6 KDa. The apparent molecular mass of the protein is approximately 69 KDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile 50mM Tris, 100mM NaCl, 10% glycerol, pH 8.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von FGFR1OP / FOP Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von FGFR1OP / FOP Protein

FOP( fibroblast growth factor receptor 1 oncogene partner) is a largely hydrophilic protein postulated to be a leucine-rich protein family member. FOP contains 1 LisH domain. A t(6;8)(q27;p11) chromosomal translocation, fusing FOP gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. FOP gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.

References

Reither A. et al., 1999, Med Klin (Munich). 94 (4): 207-10.
Guasch G. et al., 2004, Blood. 103 (1): 309-12.
Popovici C. et al., 1999, Blood. 93 (4): 1381-9.

FOP (FGFR1OP) related areas, pathways, and other information