FGF21 Antikörper (Antigen Affinität reinigt)

13.02.2012

Produkt-Information von FGF21 Antikörper

Immunogen	Recombinant Mouse FGF21 protein (Catalog#50421-M08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse FGF21 (rM FGF21;Catalog#50421-M08H; Q9JJN1; Met 1-Ser 210). FGF21 specific IgG was purified by Mouse FGF21 affinity chromatography.

FGF21 Antikörper Usage Guide

Specificity	Mouse FGF21
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse FGF21 in WB. Using a DAB detection system, the detection limit for Mouse FGF21 is approximately 2 ng/lane under non-reducing conditions and 1 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse FGF21. The detection limit for Mouse FGF21 is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von FGF21 Antikörper

Verwandte Bereiche:

Proteine:

Antikörper:

Hintergrund von FGF21 Antikörper

The fibroblast growth factors (FGFs) are a growing family of heparin-binding growth factors that regulate a variety of physiological processes in both developing and adult organism. FGFs function as key secreted signalling molecules in many developmental events. Mouse fibroblast growth factor 21 (FGF21) is a member of endocrine FGFs subfamily, along with FGF19 and FGF23. It is emerging as a novel regulator with beneficial effects on a variety of metabolic parameters, including glucose and lipid control. FGF21 functions as a metabolic regulator. The FGF21 transcript is abundantly expressed in liver. FGF21 activity depends on membrane protein betaKlotho that physically complexes with various FGF receptors, thus conferring them the ability to bind FGF21 and activate downstream signaling pathways. FGF21, like other FGFs, folds to a beta-trefoil-like core region, with disordered N- and C-termini. FGF21 recently has been proposed as a missing link in the biology of fasting, it shows significant, non-saturable, unidirectional influx across the blood-brain barrier (BBB). FGF21 is a critical metabolic regulator, pivotal for fasting adaptation and directly regulated by PPARalpha in rodents. FGF21 circulates in human plasma and increases by extreme fasting and PPARalpha activation. The wide interindividual variation and the induction of ketogenesis independent of FGF21 levels indicate that the physiological role of FGF21 in humans may differ from that in mice.

References

Hsuchou H. et al., 2007, Peptides. 28 (12): 2382-6.
Yamauchi H. et al., 2006, EMBO Rep. 7 (6): 649-54.
Izumiya Y. et al., 2008, FEBS Lett. 582 (27): 3805-10.
Arner P. et al., 2008, FEBS Lett. 582 (12): 1725-30.
Micanovic R. et al., 2009,J Cell Physiol. 219 (2): 227-34.

Sino Biological Inc. liefert FGF21 Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über FGF21 Antikörper (Antigen Affinität reinigt) lesen Sie bitte: http://www.sinobiological.com/goods.php?id=7601