Uteroglobin / SCGB1A1 Antikörper (Antigen Affinität reinigt)

Verwandte Bereiche:

Proteine:

Antikörper:

Uteroglobin (UG), or Secretoglobin 1A member 1 (SCGB1A1), a protein belongs to the secretoglobin family. Uteroglobin/SCGB1A1 also known as Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10), is a small molecular weight secreted protein found only in mammals, and mainly expressed in lung, with anti-inflammatory/immunomodulatory properties. Previous in vitro studies demonstrated that CCAAT/enhancer-binding proteins (C/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression, whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with antiinflammatory / immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A (2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its antiinflammatory activities, Uteroglobin manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. The mechanism (s) of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.

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