FGF19 Protein (Native)

18.09.2012

Produkt-Information von FGF19 Protein

Synonym	FGF19
Protein Construction	A DNA sequence encoding the mature form of human FGF19 (O95750) (Phe27-Lys216) was expressed, with a N-terminal Met.
Source	Human
Expression Host	E.coli

QC Testing von FGF19 Protein

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: FGF19 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human FGF19 consists of 191 amino acids and predicts a molecular mass of 21.4 KDa. It migrates as an approximately 23 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of 15% gly 50mM Tris 2mM EDTA. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von FGF19 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von FGF19 Protein

FGF19, also known as FGF-19, belongs to the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. It also stimulates glucose uptake in adipocytes. It is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. It interacts with KL and KLB directly. However, it interacts with FGFR4 in the presence of heparin, KL or KLB.

References

Tamimi Y. et al., 2006, Hum Mol Genet. 15 (21): 3229-40.
Goetz R. et al., 2007, Mol Cell Biol. 27 (9): 3417-28.
Harmer NJ. et al., 2004, Biochemistry. 43 (3): 629-40.

Sino Biological Inc. liefert FGF19 Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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