CD16b / FCGR3B Protein (His Tag)

Produkt-Information von CD16b / FCGR3B Protein

QC Testing von CD16b / FCGR3B Protein

Purity	> 99 % as determined by SDS-PAGE	SDS-PAGE: CD16b / FCGR3B protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gly 17
Molecular Mass	The recombinant human CD16b comprises 195 amino acids with a predicted molecular mass of 22.2 kDa. As a result of glycosylation, it migrates as an approximately 38-43 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD16b / FCGR3B Protein

Verwandte Produkte & Themen von CD16b / FCGR3B Protein

Cancer>>Cancer Stem Cell (CSC)>>CD16

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Lineage Markers>>CD16

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Granulocyte Markers / Neutrophils>>CD16

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>CD16

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>CD16

Immunology>>Fc Receptor>>CD16

Beschreibung von CD16b / FCGR3B Protein

CD16, the low affinity Fc gamma receptor III for IgG (FcgammaRIII), exists as a polypeptide-anchored form (CD16a) in human natural killer cells and macrophages and as a GPI-anchored form (CD16b) exclusively expressed on human neutrophils. CD16b is unique in that it is the only Fc receptor linked to the plasma membrane. The GPI-anchored proteins often preferentially localize to DRMs (detergent-resistant membranes) that are rich in sphingolipids and cholesterol and play an important role in signal transduction. CD16b constitutively partitions with both low- and high-density DRMs. Upon CD16b engagement, a significant increase in the amount of the receptor is observed in high-density DRMs. It is indicated that CD16b associates with complement receptor 3 (CR3, Mac-1, CD11b/CD18) which can indirectly link CD16b to the actin cytoskeleton.

References

1. Nagarajan S. et al., 1995, J Biol Chem. 270 (43): 25762-70.
2. Middelhoven P J. et al., 1999, Biochem Biophys Res Commun. 255 (3): 568-74.
3. Williams T E. et al., 2000, Biophys J. 79 (4): 1867-75.
4. Fernandes M J. et al., 2006, Biochem J. 393 (1): 351-9.

Sino Biological Inc. liefert CD16b / FCGR3B Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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