FGF14 / SCA27 (isoform1B) Protein (Native)

07.05.2012

Produkt-Information von FGF14 / SCA27 Protein

Synonym	RP11-397O8.6, FGF-14, FHF-4, FHF4, SCA27
Protein Construction	A DNA sequence encoding the human FGF14 isoform 1B (NP_787125.1) (Lys 64-Thr 252 ) was expressed and purified.
Source	Human
Expression Host	E.coli

QC Testing von FGF14 / SCA27 Protein

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: FGF14 / SCA27 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human FGF14 consisting of 190 amino acids and has a calculated molecular mass of 21.1KDa. It migrates as an approximately 18KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.5. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von FGF14 / SCA27 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von FGF14 / SCA27 Protein

FGF14 belongs to the fibroblast growth factor (FGF) family. FGF family members are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF14 probably plays a role in nervous system development and function. A mutation in FGF14 gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. Defects in FGF14 can cause spinocerebellar ataxia type 27 (SCA27). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits.

References

Wang Q. et al., 2002, Neuron. 35 (1): 25-38.
Zhao Y. et al., 2007, Am J Med Genet. 144B (3): 395-6.
Lou JY. et al., 2005, J Physiol. 569 (1): 179-93.

Sino Biological Inc. liefert FGF14 / SCA27 (isoform1B) Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über FGF14 / SCA27 (isoform1B) Protein (Native) lesen Sie bitte: http://www.sinobiological.com/FGF14-SCA27-Protein-g-9027.html