ESAM Antikörper ( FITC )

06.11.2012

Sino Biological Inc. liefert ESAM Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über ESAM Antikörper ( FITC ) lesen Sie bitte: http://www.sinobiological.com/ESAM-Antibody-g-10074.html

Produkt-Information von ESAM Antikörper

Immunogen	Recombinant Human ESAM protein (Catalog#10187-H08H)
Reagents	FITC-conjugated rabbit monoclonal antibody
Clone ID	113
Ig Type	Rabbit IgG
Concentration	5 μl/Test, 0.2 mg/ml
Formulation	Aqueous solution containing 0.5% BSA and 0.1% sodium azide
Preparation	This antibody was obtained from a rabbit immunized with purified, recombinant Human ESAM (rh ESAM; Catalog#10187-H08H; NP_620411.2; Met 1-Ala 248) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.

Usage Guide von ESAM Antikörper

Specificity

Human ESAM

Flow Cytometry

Profile of anti-ESAM reactivity on HUVEC cells analyzed by flow cytometry.

Flow cytometry was performed on a BD FACSCalibur flow cytometry system

Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.

Storage

This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Verwandte Produtke & Themen von ESAM Antikörper

Related Areas:

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>ESAM

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>ESAM

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>ESAM

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM)>>ESAM

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
ESAM	Human	ESAM/Fc Protein, Recombinant	10187-H02H
ESAM	Human	ESAM/Fc Protein, Recombinant	10187-H08H
ESAM	Human	ESAM Protein, Recombinant	10187-HCCH
ESAM	Mouse	ESAM Protein, Recombinant	50977-M08H
ESAM	Rat	ESAM Protein, Recombinant	80241-R02H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human ESAM	WB, ELISA	ESAM Antibody, Mouse MAb	10187-MM01
Human ESAM	WB, ELISA	Rabbit Polyclonal Antibody	10187-RP01
Human ESAM	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10187-RP02
Human ESAM	FCM	ESAM Antibody ( FITC )	10187-R113-F
Human ESAM	ELISA	ESAM Antibody	10187-R202

Hintergrund von ESAM Antikörper

Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain, as well as a hydrophobic signal sequence, a single transmembrane region, and a cytoplasmic domain. ESAM is specifically expressed at endothelial tight junctions and on activated platelets and performs homophilic adhesion activity. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. In addition, ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. ESAM-deficient mice were described with lowered angiogenic potential, and accordingly, overexpression of ESAM is closely associated with certain tumor growth and metastasis.

References

Hirata, Ki. et al., 2001, J. Biol. Chem. 276: 16223-16231.
Ishida, T. et al., 2003, J. Biol. Chem. 278: 34598-34604.
Wegmann, F. et al., 2006, J. Exp. Med. 203: 1671-1677.
Wegmann, F. et al., 2004, Exp. Cell. Res. 300: 121-133.
Clasper, S. et al., 2008, Cancer. Res. 68: 7293-7303.