CD31 / PECAM1 Antikörper ( FITC )

Sino Biological Inc. liefert CD31 / PECAM1 Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CD31 / PECAM1 Antikörper ( FITC ) lesen Sie bitte: http://www.sinobiological.com/CD31-PECAM1-Antibody-g-10073.html

Produkt-Information von CD31 / PECAM1 Antikörper

Usage Guide von CD31 / PECAM1 Antikörper

Specificity	Human CD31 / PECAM1
Flow Cytometry	Profile of anti-CD31 reactivity on HUVEC cells analyzed by flow cytometry. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Verwandte Produkte & Themen von CD31 / PECAM1 Antikörper

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>CD31

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Hemangioblast Marker>>CD31

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>CD31

Cancer>>Cancer Stem Cell (CSC)>>CD31

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>CD31

Cancer>>Cancer Biomarkers>>CD31

Immunology>>Adaptive Immunity>>T Cell>>T Cell Migration/Adhesion>>CD31

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM)>>CD31

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>>CD31

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Migration/Adhesion>>CD31

Hintergrund von CD31 / PECAM1 Antikörper

(PECAM-1), is a 130-kDa transmembrane glycoprotein expressed by endothelial cells, platelets, monocytes, neutrophils, and certain T cell subsets, and is the only known member of the CAM family on platelets. PECAM-1 has six Ig-homology domains that share sequence similarity with cellular adhesion molecules within the extracellular region, and an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region. Accordingly, CD31acts as a signaling molecule when appropriately engaged and creates docking sites for the Src homology 2 domain-bearing protein tyrosine phosphatase (SHP)-1 and SHP-2. PECAM-1 mediates the homotypic or heterotypic cell adhesion by binding to itself or the leukocyte integrin αvβ3, and thus plays a role in neutrophil recruitment in inflammatory responses, transendothelial migration of leukocytes, as well as in cardiovascular development. In addition, it has been shown that CD31 expression is up-regulated by LPS stimulation, and might function as a feedback negative regulator of LPS inflammatory response in macrophages.

References

1. Newman, P.J. et al., 1990, Science. 247:1219-1222.
2. Sun, J. et al., 1996, J. Biol. Chem. 271: 18561-18570.
3. Newton-Nash, D.K. and Neman, P.J. et al., 1999, J. Immunol. 163: 682-688.
4. Rui, Y.X. et al., 2007, J. Immunol. 179: 7344-7351.
5. Woodfin, A. et al., 2007, Arterioscler. Thromb. Vasc. Biol. 27: 2514-2523.

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