EPHB1 / EPHT2 (aa 565-984) Protein (GST Tag)

03.12.2012

Sino Biological Inc. liefert EPHB1 / EPHT2 (aa 565-984) Protein (GST Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über EPHB1 / EPHT2 (aa 565-984) Protein (GST Tag) lesen Sie bitte: http://www.sinobiological.com/EPHB1-EPHT2-Protein-g-9936.html

Produkt-Information von EPHB1 / EPHT2 Protein

Synonym	EPHB1, ELK, EPHT2, HEK6, NET
Protein Construction	A DNA sequence encoding the human EPHB1(AAI11745.1) (Arg565-Ala984) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Source	Human
Expression Host	Baculovirus-Insect cells

QC Testing von EPHB1 / EPHT2 Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: EPHB1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human EPHB1 /GST chimera consists of 657 amino acids and has a calculated molecular mass of 75.3 kDa. The recombinant protein migrates as an approximately 66 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 20mM Tris, 500mM NaCl, 3mM DTT, pH 8.0,10% gly. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von EPHB1 / EPHT2 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

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Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
EphB1	Human	EPHB1 / EPHT2 (aa 565-984) Protein, Recombinant, with GST Tag	11963-H20B1
EphB1	Human	EphB1 Protein, Recombinant	11963-H08H
EphB1	Mouse	EphB1 Protein, Recombinant	50479-M08H
EphB1	Mouse	EphB1 Protein, Recombinant, with GST Tag	50479-M20B

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human EphB1	WB,Elisa	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11963-RP02

Beschreibung von EPHB1 / EPHT2 Protein

Ephrin type-B receptor 1, also known as EPH-like kinase 6, Tyrosine-protein kinase receptor EPH-2, EPHB1 and EPHT2, is a single-pass type I membrane protein which belongs to the protein kinase superfamily, tyr protein kinase family and ephrin receptor subfamily. EPHB1 / EPHT2 contains two fibronectin type-III domains, one protein kinase domain and one SAM (sterile alpha motif) domain. EPHB1 / EPHT2 is a member of the Eph family of receptor tyrosine kinases that is involved in embryonic nervous and vascular system development. Over- or underexpression of certain Eph receptors has been found in some cancer samples compared to normal tissue. The Eph family tyrosine kinase receptors and their ligands have been implicated in axon guidance and neuronal migration during development of the nervous system. EPHB1 / EPHT2 could stimulate fibroblast motility on extracellular matrix in a kinase-dependent manner, which also correlated with its association with Grb7, an adaptor molecule implicated in the regulation of cell migration. EPHB1 / EPHT2 is a receptor for members of the ephrin-B family. It binds to ephrin-B1, ephrin-B2 and ephrin-B3. EPHB1 / EPHT2 may be involved in cell-cell interactions in the nervous system. EPHB1 / EPHT2 plays an important roles in diverse biological processes including nervous system development, angiogenesis, and neural synapsis formation and maturation.

References

Halladay AK. et al., 2000, Brain Res Mol Brain Res. 85 (1-2): 171-8.
Han DC. et al., 2002, J Biol Chem. 277 (47): 45655-61.
Wang JD. et al., 2007, Oncology. 73 (3-4): 238-45.
Petros TJ. et al., 2009, J Neurosci. 29 (11): 3463-74.